Splice is a science fiction horror film directed by Vincenzo Natali and co-written by Natali, Antoinette Terry Bryant, and Doug Taylor. The film stars Adrien Brody and Sarah Polley as two brilliant genetic engineers, Clive Nicoli and Elsa Kast, who push the boundaries of science and ethics in their quest for discovery.

The story revolves around Clive and Elsa, who work for a biotech company where they successfully splice together the DNA of various animals to create hybrid creatures for medical research. Seeking to achieve greater breakthroughs, they decide to experiment with human DNA, creating a new organism named Dren (delphin + human + alien). Dren, portrayed by Delphine Chanéac, initially resembles a humanoid creature but undergoes rapid growth and development, exhibiting increasingly complex behavior and emotions.

As Dren matures, she develops a unique bond with Clive and Elsa, but their creation soon becomes unpredictable and dangerous. The film explores themes of scientific ambition, the ethics of genetic manipulation, and the consequences of playing god. As Dren’s true nature unfolds, tensions rise, leading to horrific and unexpected outcomes.

Splice received mixed reviews, praised for its thought-provoking premise, strong performances, particularly from Brody and Polley, and its blend of horror and sci-fi elements.

The film delves into the moral implications of genetic engineering and the emotional turmoil of its characters, making it a compelling watch for fans of the genre. With its unsettling atmosphere and shocking twists, Splice challenges viewers to consider the ethical limits of scientific exploration.

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